Protocol for a single arm feasibility trial assessing home-based pulmonary rehabilitation for adults with idiopathic pulmonary fibrosis in Delhi, India

Clinical Research Results Abstract Research Idea Abstract Outline of the research question-: Is home-based pulmonary rehabilitation (PR), delivered using a paper-based manual, for adults with idiopathic pulmonary fibrosis (IPF) in Delhi, India feasible?Background-IPF often results in poor exercise tolerance, dyspnoea, and reduced quality of life. There are increasing cases and recognition of IPF in India, however treatment for IPF is mainly limited to anti-fibrotic. Guidelines recommend PR, which can be centre based, home-based or delivered virtually/remotely. However, with poor availability of PR centres, patients find it difficult to access PR services easily; a problem exacerbated by the pandemic. At present, data is lacking on the feasibility of conducting home-based PR in adults with IPF living in India. Our aim is to provide easy access to PR via home-based programme with paper-based exercise manual (Figure 1 Example of manual adaptation)Possible Methodology-A single-arm feasibility trial of home-based PR using the SPACEforCOPD© paper-based manual for adults living with IPF in Delhi, India, including pre-trial qualitative evaluation from adults with IPF, family caregivers and healthcare professionals. This study is approved by the ethics review committee of Metro Hospitals & Heart institute, Noida, India (62/MERB/2021) and University of Leicester, UK (31989). The primary outcome measures include the comprehensive assessment of the feasibility of patient recruitment and the intervention delivery (screening, suitability of the inclusion criteria, and operational experience of intervention delivery).Questions to discuss-Is it feasible and acceptable to conduct home-based PR with adult with IPF in India? Will the intervention be acceptable for PR deliverers? Will there be any changes in health of the adults living with IPF following completion of home-based PR based on the adapted SPACEforCOPD© manual? Service Development & Evaluation Abstract Declaration of Interest Declaration of Interest-This research was funded by the National Institute for Health Research (NIHR) (17/63/20) using UK aid from the UK Government to support global health research. References and Clinical Trial Registry Information References-Apps LD, et al. Int J COPD, 2013; 8: 317–327. https://doi.org/10.2147/COPD.S40414 Mitchell KE, et al. Eur Respir J, 2014; 44: 1538–1547. https://doi.org/10.1183/09031936.00047814 Raghu G, et al. Am J Respir Criti Care Med, 2011; 183: 788–824. https://doi.org/10.1164/rccm.2009-040GL Singh SJ, et al. Lancet Respir Med, 2019; 7: 1002–1004. https://doi.org/https://doi.org/10.1016/S2213-2600(19)30364-9 Clinical trail registry information- CTRI/2021/10/037511