Are there differences in relation to consumption of inhaled corticosteroids depending on age and gender in adult asthma patients? A descriptive cohort study

Clinical Research Results Abstract Introduction: Asthma is characterized by chronic airway inflammation with partially or fully reversible airflow obstruction. Appropriate treatment, with inhaled glucocorticosteroids (ICS) can control the disease. Our aim it to see if behavior patterns in relation to consumption of ICS are related to age and sex . Other possible confounding factors will also be analyzed.Methods: Descriptive cross-sectional study of the anonymous MAJORICA population cohort which includes 70,845 patients over 18 years old diagnosed with asthma and/or COPD. We included patients with asthma and treated with ICS for at least 90 days in a 2 years time. Variables were: behavior pattern in relation to consumption of prescribed ICS , gender, age, smoking history, comorbidities, SABA use and hospitalizations. Bivariate analysis was performed to analyze the relationship between gender, age and treatment behavior pattern and multivariate logistic regression analysis to assess interactions and confounding factors.Results: 5,133 patients were included, mean age was 55.4, 3402 were women and 20% smokers. 21.1% had a prescribed ICS consumption of 80%-120% and 11.9% greater than 120%. No differences in behavior patterns in relation to consumption of ICS was found by sex (P=0.27), however, a gradient was observed in prescribed ICS consumption and treatment abuse as age increased. Other factors associated to higher consumption of ICS were the number of asthma hospitalizations, SABA use, comorbidities and being an ex-smoker.Discussion: No differences in consumption of prescribed inhaled corticosteroids (ICS) were found between men and women. Age could increase prescribed ICS consumption particularly in those over 55.Declaration of interest: Astrazeneca grant Research Idea Abstract Service Development & Evaluation Abstract Declaration of Interest References and Clinical Trial Registry Information