Functional Respiratory Imaging (FRI) Assessment of Modelled Lung Deposition in an Asthmatic patient: Comparing MDI/Spacer and DPI Delivery Systems

Clinical Research Results Abstract INTRODUCTION: Both Metered Dose Inhalers (MDIs) and Dry Powder Inhalers (DPIs) can be used to deliver drugs to manage Asthma. Valved Holding Chambers (VHCs) / Spacers can be used to help patients with inhalation coordination of their MDIs. Inspiratory flow rate is known to influence drug delivery. This FRI based study assessed the modelled airway drug delivery from an MDI/VHC system and two DPI systems at optimal and sub optimal flow rates.METHODS: Three dimensional geometries of airways and lobes were extracted from a CT scan of a 21 year old male Asthma (moderate) patient. Drug delivery and airway deposition of MDI/VHC delivered albuterol (VentolinÒ HFA) was modelled using FRI with measured particle and plume characteristics with an AeroChamber PlusÒ Flow-VuÒ VHC. Symbicort (budesonide/formoterol) Turbohaler and Seretide (fluticasone/salmeterol) Diskus DPIs were similarly modelled. Inhalation flow rates of 30 L/min (optimum for MDI/VHC, sub optimal for DPIs) and 60 L/min (optimum for DPIs, sub optimal for MDI/VHC) were assessed.RESULTS: The modelled lung deposition results are shown in the chart, expressed as a percentage of label dose, using both optimal and sub-optimal inhalation flow rates.DISCUSSION: The FRI deposition profiles highlight that the MDI/AeroChamber PlusÒ Flow-VuÒ VHC system delivered a significantly greater percentage of drug to the lung region than either of the two DPIs. The influence of inhalation flow profile was less with the MDI/VHC system and differed between the two DPIs. Research Idea Abstract Service Development & Evaluation Abstract Declaration of Interest I am employed in a Scientific and Clinical capacity by a Medical Device organisation. References and Clinical Trial Registry Information